Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cervical lymph node metastasis high metastatic HNSCC lines vs non-metastatic HNSCC lines

ABSTRACT: This study is the orthotopic nude mouse model of Head and neck squamous cell carcinoma (HNSCC).

ORGANISM(S): Homo sapiens

PROVIDER: GSE79637 | GEO | 2019/03/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)

Project description:A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.

2005-01-09 | E-UMCU-11 | biostudies-arrayexpress

Expression data of HNSCC cell lines in normoxia and hypoxia

Project description:Hypoxia has been linked to increased treatment resistance in many solid tumors, including head and neck squamous cell carcinoma (HNSCC). We aim to identify genes involved in hypoxia-mediated response to radiotherapy in HNSCC. We used microarrays to investigate the influence of hypoxia on the global gene expression in HNSCC.

2021-08-27 | GSE182734 | GEO

A Novel Orthotopic Mouse Model of Head and Neck Cancer and Lymph Node Metastasis

Project description:Analysis of the genes involved in the metastasis of head and neck squamous cell carcinoma (HNSCC). We hypothesized that there would be overexpression of certain genes in the highly metastatic USC-HN1-GFP-G1 and USC-HN1-GFP-G2 cell lines compared to the parental USC-HN1-GFP cell line. We used the USC-HN1 cell line stably transfected with H2B-GFP and developed an immortal cell line (USC-HN1-GFP), which was injected into the tongues of SCID/nude mice. The metastatic cells were collected at the LN, separated and cultured, forming an immortal USC-HN1-GFP-G1 cell line. These cells were reinjected into the tongues of mice and the USC-HN1-GFP-G2 cell line was formed by the same LN collection method. The gene expression in these three cell lines were compared using Illumina microarray chips.

2012-10-29 | E-GEOD-41893 | biostudies-arrayexpress

Open chromatin profile of primary and lymph node oral cancer cells

Project description:We employed FAIRE-seq to identify open chromatin in head and neck squamous cell carcinoma (HNSCC) patient-derived primary and lymph node cell lines. We further analysed this data to identify differential open chromatin between primary and metastatic cells.

2017-09-14 | GSE92479 | GEO

miRNA expression in head and neck squamous cell carcinoma (HNSCC)

Project description:The involvement of microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis, prognosis and response to therapy is becoming increasingly appreciated. The etiology of head and neck squamous cell carcinoma (HNSCC) is predominantly associated with the synergistic effects of tobacco and alcohol use, as well as Human Papilloma Virus (HPV) infection, which embodies a distinct clinical and biological phenotype. We sought to examine whether the profile of miRNAs in HNSCC varies based on HPV status, and to identify specific miRNAs altered in head and neck carcinogenesis. Total RNA was isolated from 16 HNSCC fresh frozen primary tumors, 5 fresh frozen non-diseased head and neck epithelial tissues, and 2 HNSCC cell lines. The miRNA profile of 662 individual miRNAs in these tissues was examined by microarray. 18 miRNAs are significantly altered in their expression between normal tissues and HNSCC tumors and 5 miRNAs are identified as significantly differentially expressed between HPV-positive (HPV+) and HPV-negative (HPV-) tumors. A striking difference in expression pattern of miRNA was also observed between primary tissues and cell lines. These data suggest that the pattern of miRNA expression may be reflective of disease etiology, and may be useful in the realm of diagnostic biomarkers defining broadly responsive prevention and treatment strategies for HNSCC. These data also suggest that cultured tumor cell lines may be inappropriate for novel miRNA biomarker identification. Keywords: miRNA; Disease-state analysis Expression of 662 individual miRNA was assessed in16 HNSCC fresh frozen primary tumors, 5 fresh frozen non-diseased head and neck epithelial tissues, and 2 HNSCC cell lines were arrayed

2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress

A Novel Orthotopic Mouse Model of Head and Neck Cancer and Lymph Node Metastasis

2012-10-29 | GSE41893 | GEO

iTRAQ-based quantitative proteomics analysis of human HNSCC cells

Project description:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and is major cause of cancer mortality and morbidity. It emerges within oral cavity, lip, tongue, floor of the mouth, nasopharynx, palate, gingival and larynx, is common cancer worldwide especially in Southeast Asia and Southern China. Despite of the advancements in the understanding of the HNSCC as the disease, the 5 year survival rate remains unchanged at 50% since last three decades. Factors such as advanced stage presentation of the patient and consequent delay in diagnosis contributes to the bleak scenario. Thus, therefore there is dire need of useful biomarkers that can predict HNSCC in early stages and can serve as prognostic indicators or targets for treatment. In the present study, We used iTRAQ (isobaric tags for relative and absolute quantitation)-based quantitative proteomic approach followed by liquid chromatography and high resolution tandem mass spectrometry (LC-MS/MS) to identify differential proteins from head and neck cancer cell lines.

2015-01-29 | PXD000737 | Pride

Microarray analysis of LncRNAs expression in metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) and non-metastatic HNSCC tissues

Project description:Microarray analysis of LncRNAs expression in metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) and non-metastatic HNSCC tissues

| PRJNA1031554 | ENA

Microarray analysis of LncRNAs expression in metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) and non-metastatic HNSCC tissues

Project description:Analysis of different LncRNA expression in 4 paired metastatic HNSCC and non-metastatic HNSCC samples

2023-12-27 | GSE246104 | GEO

delta-Np63 loss of function study in the HNSCC cell line UT-SCC-74A

Project description:delta-Np63 is highly expressed in squamous cell carcinoma of the head and neck (HNSCC). To evaluate its function in HNSCC we depleted delta-Np63 by siRNAs in the HNSCC cell line UT-SCC-74A. The transcriptome was analysed by cDNA microarray.

2016-01-14 | E-MTAB-3670 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data