Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ShRNA cassette sequencing from disomic and trisomic fibroblasts cultured in the presence of shRNA kinome library for 14 days

ABSTRACT: Kinome-wide shRNA screen to identify kinases differentially required for survival of cells disomic and trisomic for chromosome 21

ORGANISM(S): Homo sapiens

PROVIDER: GSE79840 | GEO | 2016/07/29

SECONDARY ACCESSION(S): PRJNA317171

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

shRNA cassette sequencing from disomic and trisomic fibroblasts cultured in the presence of shRNA kinome library for 14 days

Project description:Kinome-wide shRNA screen to identify kinases differentially required for survival of cells disomic and trisomic for chromosome 21 Cells were transduced in triplicate and propagated for 14 days to allow for enrichement or depletion of shRNAs from the population

2016-07-29 | E-GEOD-79840 | biostudies-arrayexpress

RNAseq from disomic and trisomic fibroblasts and lymphoblastoids

Project description:RNA was sequenced from individuals Disomic and Trisomic for chromosome 21 to identify consistent changes in gene expression across individuals

2016-07-29 | GSE79842 | GEO

RNAseq from disomic and trisomic T cells and monocytes

Project description:RNA was sequenced from Disomic and Trisomic individuals for chromosome 21 to identify consistent changes in gene expression across individuals

2016-07-29 | GSE84531 | GEO

RNAseq from disomic and trisomic fibroblasts and lymphoblastoids

Project description:RNA was sequenced from individuals Disomic and Trisomic for chromosome 21 to identify consistent changes in gene expression across individuals Cells were cultured at subconfluency and RNA harvested for sequencing

2016-07-29 | E-GEOD-79842 | biostudies-arrayexpress

RNAseq from disomic and trisomic T cells and monocytes

Project description:RNA was sequenced from Disomic and Trisomic individuals for chromosome 21 to identify consistent changes in gene expression across individuals Cells were cultured at subconfluency and RNA harvested for sequencing

2016-07-29 | E-GEOD-84531 | biostudies-arrayexpress

Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21

Project description:Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations throughout the genome. These transcriptome changes are likely to underlie the Down syndrome clinical phenotypes. We have employed RNA-seq to undertake an in-depth analysis of transcriptome changes resulting from trisomy of chromosome 21, using induced pluripotent stem cells (iPSCs) derived from a single individual with Down syndrome. These cells were originally derived by Li et al, who genetically targeted chromosome 21 in trisomic iPSCs, allowing selection of disomic sibling iPSC clones. Analyses were conducted on trisomic/disomic cell pairs maintained as iPSCs or differentiated into cortical neuronal cultures.

2018-04-09 | GSE101942 | GEO

Synthetic lethal siRNA screen for TN-IBC cell line SUM149PT using kinome library with EPA treatment

Project description:Synthetic lethal siRNA screen using a kinome library containing 939 druggable genes in the TN-IBC cell line SUM149PT, in combination with EPA treatment.

2019-01-31 | GSE102057 | GEO

Blood cells with trisomy 21 overreact to heat shock stress [PRO-seq]

Project description:Lymphoblastoid cells trisomic for chromosome 21 activate the heat shock response more robustly than disomic cells.

2023-04-21 | GSE173537 | GEO