Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential gene expression profiling of resting Vs proliferating Treg cells from NOD mice G-BMDC-T-cell co-cultures

ABSTRACT: Resting and proliferating Treg cells from NOD mice G-BMDC-Treg co-cultures were sorted out and anlyzed for differential gene expresion pattern. Proliferating Treg cells had increased expression of )X40, Notch and IL-2R related genes inaddition to Foxp3 and its functional partners genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE81051 | GEO | 2016/05/04

SECONDARY ACCESSION(S): PRJNA320382

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comparison of immature BMDC to BMDC after nkt cell modulation

Project description:Analyze the gene expression profile of BMDC before and after nkt cell modulation.

2009-10-17 | GSE18547 | GEO

Transcription profiling of mouse primary FDC and BMDC

Project description:expression profiles of FDC and BMDC are compared Experiment Overall Design: expression profiles of FDC and BMDC are compared

2008-06-13 | E-GEOD-4535 | biostudies-arrayexpress

Expression data from BMDC

Project description:Expression data from BMDC

| PRJNA435415 | ENA

Gene expression dynamics of Flt3L induced ex vivo BMDC differentiation

Project description:To understand the gene expression dynamics during Flt3L induced Bone-marrow derived dendritic cell (BMDC) differentatiion we performed RNA-seq. Three distinct stages were chosen and included the initial bone marrow cells, the Common Myeloid Progenitor (CMP), and fully differentiated BMDC.

2023-11-06 | GSE107026 | GEO

DNA methylation dynamics of Flt3L induced ex vivo BMDC differentiation

Project description:To understand the DNA methylation dynamics during Flt3L induced Bone-marrow derived dendritic cell (BMDC) differentatiion we performed reduced representation bisulfite sequencing (RRBS). Three distinct stages were chosen and included the initial bone marrow cells, the Common Myeloid Progenitor (CMP), and fully differentiated BMDC.

2023-11-06 | GSE107027 | GEO

Efficient IL-2R signaling differentially affects stability, function, and composition of the regulatory T cell pool

Project description:Signaling via the interleukin 2 receptor (IL-2R) is a requisite for Treg cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function during both resting and inflammatory conditions. Here, we characterized a spontaneous mouse mutant endowed with a hypomorphic Tyr129His variant of CD25, the a chain of the IL 2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under non-inflammatory conditions Cd25-Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune diseases. In contrast, Cd25-Y129H Treg cells failed to efficiently induce immune suppression and lost linage commitment in a T cell transfer colitis model, indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments. Moreover, single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets. Thus, partial loss of IL-2R signaling differentially interferes with maintenance, heterogeneity and suppressive function of the regulatory T cell pool.

2021-01-15 | GSE161345 | GEO

Gene expressions of BMDC with or without Rbpj

Project description:cDNA microarray data of Bone marrow-derived dendritic cells (BMDC) with or without Rbpj gene

2017-11-27 | GSE100593 | GEO

Expression data from BMDC cells with or without Sendai virus infection

Project description:Innate immunity is the first line of defense against viral and microbial pathogens. BMDC is critical for innate immunity. To investigate the complicated net signaling after virus invasion, we did a cDNA microarray analysis of BMDC with or without Sendai Virus infection. We used microarrays to find proteins that upregulated by Sendai Virus infection and investigated if these proteins had functions in regulating Sendai Virus induced signaling pathway. BMDC cells are seperated from C57BL6 mice, infected with Sendai Virus or not,cultured and harveseted for RNA extraction and hybridization on Affymetrix microarrays

2011-12-08 | E-GEOD-32499 | biostudies-arrayexpress

Mus musculus isolate:BMDC

Project description:Mus musculus isolate:BMDC Raw sequence reads

| PRJNA639217 | ENA

An essential role for the IL-2 receptor in Treg cell function

Project description:Regulatory T (Treg) cells, expressing abundant amounts of the IL-2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature implied a key role for a simple network based on IL-2 consumption by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg lineage specification factor Foxp3, confounding experimental efforts to understand the role of IL-2R expression and signaling in Treg suppressor function. Using genetic gain and loss of function approaches, we demonstrate that IL-2 capture is dispensable for control of CD4+ T cells, but is important for limiting CD8+ T cell activation, and that IL-2R dependent STAT5 transcription factor activation plays an essential role in Treg suppressor function separable from T cell receptor signaling.

2016-08-29 | GSE84553 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data