Transcriptomics

Dataset Information

0

Expression data from Tbet+ and Tbet- Memory B cells


ABSTRACT: The role of antibody and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell-expressed T-bet influence the host-pathogen balance during persisting infections is unclear. Here we demonstrate that B cell specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells not only controlled IgG2a production, but also mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a since T-bet in B cells was im­portant even in the presence of virus-specific IgG2a. Our data supports a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages. Naïve, Tbet+, and Tbet- Memory B cells were assayed for gene expression

ORGANISM(S): Mus musculus

PROVIDER: GSE81189 | GEO | 2016/08/01

SECONDARY ACCESSION(S): PRJNA320853

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-08-01 | E-GEOD-81189 | biostudies-arrayexpress
2019-04-29 | GSE118984 | GEO
2021-05-10 | GSE168240 | GEO
| PRJNA706657 | ENA
2019-04-29 | GSE83697 | GEO
2023-04-11 | GSE229288 | GEO
2016-01-23 | GSE77145 | GEO
2022-01-27 | GSE192765 | GEO
2022-01-27 | GSE150139 | GEO
| PRJNA706663 | ENA