Tbet regulates the transcriptional programming of Be1 B cells.
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ABSTRACT: To investigate the role of Tbet in B cell differentiation to "effector-like" antibody secreting cells (ASC's) we utilized an ex vivo culture system to differentiate B cells (Be1 cells) in the presence of Th1 polarized T cells. To determine the role of Tbet in Be1 cell differentiation we performed RNA-seq on Wt Be1 and Tbet negative (TbetNeg) Be1 cells. Collectively, these data show that T-bet serves as master regulator for the Be1 cell fate and is required for induction of genes required for ASC differentiation in Be1 cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE83697 | GEO | 2019/04/29
REPOSITORIES: GEO
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