Genomics

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MicroRNA expression signatures for colon cancer initiating cell in CRC


ABSTRACT: In CCICs, G9a expression significantly increases K-RAS protein expression but has no effect on mRNA level. This raises the question of whether microRNA (miRNA) is involved in regulation. A heat map of a miRNA array in G9a versus shG9a transfectants ranked the Let-7 family first, with only Let-7b consistently up-regulated in G9a-knockdown CCICs and down-regulated in G9a-overexpressed non-CCICs

ORGANISM(S): Homo sapiens

PROVIDER: GSE82130 | GEO | 2016/08/10

SECONDARY ACCESSION(S): PRJNA324110

REPOSITORIES: GEO

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