Transcriptomics

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Polysomal and total RNA in controls and after 10 min global brain ischemia and 8 hours of reperfusion


ABSTRACT: Complete global brain ischemia (CGBI) and reperfusion occur following resuscitation from cardiac arrest. Different brain neurons are selectively vulnerable to CGBI: pyramidal neurons of hippocampal CA3 survive 10 min CGBI but those of CA1 die at 3 days following 10 min CGBI. CA3 neurons are expected to have more robust stress responses and repair responses than CA1 neurons. We used microarrays to compared total and polysome-bound mRNAs in CA1 and CA3 at 8 hr reperfusion after 10 min CGBI in Long Evans male rats to ascertain differences in total vs polysome-bound gene expression.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE82146 | GEO | 2016/06/02

SECONDARY ACCESSION(S): PRJNA324171

REPOSITORIES: GEO

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