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Transcriptome profiling of hematopoietic cells derived from human pluripotent stem cells

ABSTRACT: We performed morphogen-directed differentiation of human PSCs into HE followed by combinatorial screening of 26 candidate HSC-specifying TFs for the potential to promote hematopoietic engraftment in irradiated immune deficient murine hosts. We recovered seven TFs (ERG, HOXA5, HOXA9, HOXA10, LCOR, RUNX1, SPI1) that together were sufficient to convert HE into hematopoietic stem and progenitor cells (HSPCs) that engraft primary and secondary murine recipients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE83719 | GEO | 2017/05/17

SECONDARY ACCESSION(S): PRJNA326819

REPOSITORIES: GEO

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