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Linkages between 3D genome organization and transcriptome during muscle cell development

ABSTRACT: This study aimed to interrogate the interrelationship between 3D genome organization and global gene expression during muscle development using a mouse C2C12 cell line as an in vitro model. The C2C12 cell line is a well-established and extensively studied in vitro model derived from serial passage of myoblasts cultured from the thigh muscle of C3H mice after a crush injury. C2C12 cells divide when mitogens are present in the culture medium and spontaneously differentiate into muscle-like multinucleated (myotubes) cells if the medium is depleted of mitogens (i.e. serum; (Bischoff 1986)).

ORGANISM(S): Mus musculus

PROVIDER: GSE84279 | GEO | 2017/04/07

SECONDARY ACCESSION(S): PRJNA328513

REPOSITORIES: GEO

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