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Expression analysis of transgenic mice with a cardiac specific overexpression of DSC2.

ABSTRACT: Gene expression data indicate an early up-regulation of inflammatory and fibrotic remodeling pathways in DSC2 transgenic mice vs. non-transgenic control mice. The mice were analyzed at the age of 3.5 and 13 weeks. The mice were analyzed at the age of 3.5 and 13 weeks.

ORGANISM(S): Mus musculus

PROVIDER: GSE84645 | GEO | 2016/07/21

SECONDARY ACCESSION(S): PRJNA330724

REPOSITORIES: GEO

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Expression analysis of transgenic mice with a cardiac specific overexpression of DSC2.

Project description:Gene expression data indicate an early up-regulation of inflammatory and fibrotic remodeling pathways in DSC2 transgenic mice vs. non-transgenic control mice. The mice were analyzed at the age of 3.5 and 13 weeks. The mice were analyzed at the age of 3.5 and 13 weeks. Seven DSC2 transgenic and seven non-transgenic control mice were analyzed at the age of 3.5 and 13 weeks.

2016-07-21 | E-GEOD-84645 | biostudies-arrayexpress

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Cardiac transcriptome analysis of BBLN-transgenic mice by NGS

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Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS

Project description:The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G-protein-coupled receptor kinase 2 (GRK2). By inhibition of the proto-oncogenic and pro-survival RAF1-MAPK pathway, the RAF kinase inhibitor protein, RKIP, acts as a tumor suppressor, which enhances cardiomyocyte death and promotes the development of symptoms of heart failure. To elucidate pathomechanisms of heart failure induced by RKIP, the study determined the cardiac transcriptomes of eight-month-old, male, transgenic mice with cardiac-specific expression of RKIP (PEBP1) under control of the myocardium-specific, alpha-MHC promoter. In addition, the study determined the cardiac transcriptomes of GRK2-transgenic mice. Tg-GRK2 mice have a slightly increased transgenic expression of GRK2. According to NGS data, cardiac GRK2-Grk2 transcript levels of Tg-GRK2 mice are 1.59±0.10-fold higher than those of non-transgenic FVB hearts. In Tg-GRK2 mice, transgenic GRK2 is expressed under control of the ubiquitous CMV immediate-early promoter/enhancer. The non-transgenic control group are age-matched, male, nontransgenic FVB/N mice. NGS data of this study document transcriptome changes underlying the heart failure phenotype induced by transgenic RKIP expression and cardiac degeneration induced by GRK2 expression.

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Cardiac gene expression after transgenic overexpression or deletion of MeCP2 in cardiomyocytes

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Project description:Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS

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