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Expression profiling and occupancy after knockdown or over-expression of HFN1A or HNF4G in prostate cancer cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85559 | GEO | 2017/11/01

SECONDARY ACCESSION(S): PRJNA338783

REPOSITORIES: GEO

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Expression profiling and occupancy after knockdown or over-expression of HFN1A or HNF4G in prostate cancer cells

Project description:Expression profiling and occupancy after knockdown or over-expression of HFN1A or HNF4G in prostate cancer cells

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Expression of HNF4G and its potential functions in lung cancer.

Project description:The hepatocyte nuclear factor 4 gamma (HNF4G), a member of orphan nuclear receptors, is up-regulated and functions as an oncoprotein in bladder cancer. In the present study, we observed that HNF4G expression was elevated in lung cancer tissues as compared to adjacent normal lung tissues. The expression of HNF4G protein was correlated with the tumor size and the prognosis of patients. Transfection with a small interference RNA (siRNA) targeting HNF4G in two lung cancer cell lines (H358 and H292 cells) significantly inhibited cell proliferation via arresting cells at G1 phase and inducing cell apoptosis. In addition, HNF4G siRNA reduced cell proliferation in a xenograft tumor-bearing model. Moreover, A549 cells, which had relative lower level of HNF4G, were ectopic expressed with HNF4G and treated with an AKT inhibitor (MK-2206). MK-2206 exposure not only attenuated the promoting effects of HNF4G overexpression on cell proliferation and cell cycle progression, but also suppressed the inhibitory effects of HNF4G overexpression on cell apoptosis. These data suggested that AKT signaling pathway was a potential upstream mediator of HNF4G. Collectively, our data indicate that HNF4G exerts as an oncogenic role in lung cancer by promoting cell proliferation and that HNF4G expression is a potential prognosis factor for lung cancer.

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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HNF4G, AR, FOXA1, H3K4me1, H3K27acetyl binding sites upon knockdown and overexpression of HNF4G in 22Rv1 and LNCaP prostate cancer cells respectively

Project description:HNF4G is a gastrointestinal tissue enriched master transcriptional regulator seen overexpressed in a subset of prostate cancer. Here we have mapped binding sites of HNF4G, AR, Foxa1, H3K4me1, H3K27acetyl upon knockdown and overexpression of HNF4G in in 22Rv1 and LNCaP cells respectively

2017-11-01 | GSE85558 | GEO

Effect of NDRG3 over-expression and knockdown on cell response to hypoxia

Project description:This SuperSeries is composed of the SubSeries listed below.

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Gene expression profile of LNCaP prostate cancer cells with exogenous HNF4G expression

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2017-11-01 | GSE85244 | GEO

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