Epithelial-mesenchymal transition markers screenedina cell-based model and validated in lung adenocarcinoma
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ABSTRACT: The epithelial-to-mesenchymal transition (EMT) process in cancer enables the migratory and invasive capabilities associated with metastatic competence. The cancer microenvironment plays an important role in inducing the occurrence of EMT. A number of extracellular stimuli and associated signaling pathways have been identified to promote EMT, however, molecular features during the early stages of EMT are poorly understood. Here we have established a novel in vitro EMT-inducing system that mimi cs tumor microenvironment and allows for close monitoring of the EMT progress. Using RNA-seq and miRNA-seq, we analyzed the transcriptomic transitions accompanying the progression of EMT, and pinpointed several molecular features during early EMT of the lung carcinoma cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE90133 | GEO | 2019/06/26
REPOSITORIES: GEO
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