Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression in the human VTA of cases with alcohol abuse

ABSTRACT: Drugs of abuse including nicotine and alcohol elicit their effect by stimulating the mesocorticolimbic dopaminergic system. There is a high incidence of nicotine dependence in alcoholics. To date only limited data is available on the molecular mechanism underlying the action of alcohol and nicotine in the human brain. This study utilised gene expression screening to identify genes sensitive to chronic alcohol abuse within the ventral tegmental area of the human brain. Keywords: gene expression, brain, alcohol abuse, human, ventral tegmental area

ORGANISM(S): Homo sapiens

PROVIDER: GSE9058 | GEO | 2007/09/21

SECONDARY ACCESSION(S): PRJNA102573

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem ventral tegmental area (VTA) of subjects with alcohol use disorder

Project description:Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem ventral tegmental area of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. Front Genet 2019; 10, 614). AUD-associated mRNA transcriptomic changes were analyzed by the Limma-Voom method. Results: Differentially expressed mRNAs (absolute FC>2.0 & P<0.05) were identified in postmortem ventral tegmental area of subjects with alcohol use disorder (AUD). Chronic alcohol consumption may alter mRNA transcriptome profiles in reward-related brain regions, resulting in alcohol-induced neuroadaptations.

2021-10-13 | GSE182649 | GEO

RNA-sequencing in rat ventral tegmental area (VTA) following chronic ethanol and withdrawal

Project description:The objective of The Center for Alcohol Research in Epigenetics (CARE) is to identify gene regulatory pathways in ventral tegmental area (VTA) that are altered in response to chronic ethanol administration and withdrawal.

2024-02-15 | GSE233921 | GEO

24-hour transcriptome profile in the murine VTA

Project description:This study aimed at identifying rhythmically regulated transcripts in the ventral tegmental area (VTA) of mice. Punch biopsies of the VTA from C57BL/6 brain slices were prepared at 6 different timepoints across the day and analyzed for transcriptome regulation

2019-01-30 | GSE125812 | GEO

Correlating behavoir and molecular endpoints indentifies IFNγ-regulated genes in the dopaminergic system after modafinil administration in mouse

Project description:The mechanisms of aciotn of modafinil continue to be poorly characterised and its potential for abuse remains controverted. The aim of this study was to further elucidate the mechanism of action of modafinil, through a potential behavioural and molecular association in the mouse. A conditioned place preference (CPP) paradigm was implemented to investigate the rewarding properties of modafinil. Whole genome expression and qRT-PCR analysis were performed on the ventral tegmental area (VTA), nucleus accumbens (NAC) and prefrontal cortex (PFC) of modafinil-treated and control animals. We used microarrays to detail gene expression in the ventral tegmental area (VTA), nucleaus accumbens (NAC) and prefrontal cortex (PFC) of the vehicle and modafinil treated animals to profile whole genome expression in the selected brain regions.

2015-10-15 | GSE74010 | GEO

Molecular profiling of prelimbic projections to NAc, BLA, and VTA using vTRAP

Project description:Translational profiling of prelimbic cortical projections to nucleus accumbens, basolateral amygdala, and ventral tegmental area was performed. Studies were performed using AAV5-IV-GFPL10 (in prelimbic cortex) in tandem with CAV2-Cre (in the projection target), which enables rapid, projection-specific translational profiling.

2017-10-14 | GSE104943 | GEO

GNPS - Ventral Tegmental Area of Murine Brain in Caffeine/Alcohol Study

Project description:Untargeted profiling of brain ventral tegmental area (VTA) in a mouse model looking at caffeine and alcohol interactions. Extraction with MeOH/H2O 50/50. Analyzed with a 5 cm C18 column and 10 minutes gradient elution. Internal standard Sulfadimethoxine-d5.

2024-03-01 | MSV000094216 | GNPS

Brain Proteomic Atlas of Alcohol Use Disorder in Adult Males

Project description:Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs including the brain. Multi-omic analyses of the brain from individuals with AUD to date lack a comprehensive analysis of protein alterations in the multiple brain regions that underlie neuroadaptations occurring in AUD. We performed quantitative proteomic analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of human post-mortem tissue from brain regions that play a key role in the development and maintenance of AUD: amygdala (AMG), hippocampus (HIPP), hypothalamus (HYP), nucleus accumbens (NAc), prefrontal cortex (PFC) and ventral tegmental area (VTA). Brain tissues analyzed were from individuals with AUD (n = 11) and matched controls (n = 16).

2023-10-24 | PXD040884 | Pride

RNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain

Project description:RNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain

2015-07-27 | GSE64452 | GEO

RNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain

Project description:RNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain Murine midbrain dopaminergic neurons from the SNpc and VTA regions

2015-07-27 | E-GEOD-64452 | biostudies-arrayexpress

Comparison of Differences in Gene Expression in brain of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption

Project description:This SuperSeries is composed of the following subset Series: GSE31695: Comparison of Differences in Gene Expression in the Ventral Tegmental Area of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption GSE31705: Comparison of Differences in Gene Expression in the Nucleus Accumbens Shell of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption GSE31708: Comparison of Differences in Gene Expression in the Central Nucleus of the Amygdala (CeA) of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption Refer to individual Series

2012-07-31 | E-GEOD-31709 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data