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Effect of odor inhalation of rats with restraint stress on their hypothalamic gene expression profiles

ABSTRACT: To uncover molecular mechanisms underlying reduction of responses to restraint stress by racemic (R,S)-linalool inhalation, gene expression profiling at the hypothalamus of restraint stressed rats exposed to racemic (R,S)-linalool was carried out. Inhaled (R,S)-linalool returned the expression of 560 stress-induced probe sets to a normal status. These genes were associated with synaptic transmission via neurotransmitters including anxiolytic neuropeptides such as oxytocin and neuropeptide Y, and also included a number of major histocompatibility complex (MHC) class I necessary for neural development and plasticity. These results reveal some of the molecular mechanisms for odor inhalation under stress condition at the hypothalamus.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE90923 | GEO | 2017/06/16

SECONDARY ACCESSION(S): PRJNA356371

REPOSITORIES: GEO

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