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Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus

ABSTRACT: Using RNA sequencing technology, we compared speciﬁc changes in the transcriptomic proﬁles in human foreskin fibroblast cells (HFF-1) following ORFV infection. ORFV speciﬁcally upregulated and downregulated a variety of genes, including genes involved in antiviral immune response, apoptosis, cell cycle and a series of signaling pathways, such as the IFN and p53-signaling pathways. A range of genes were downregulated at early stage. In contrast, the virus up-regulates a number of cellular genes at late stage.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93226 | GEO | 2017/01/07

SECONDARY ACCESSION(S): PRJNA360374

REPOSITORIES: GEO

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