Expression data from livers of ad libitum and calorie-restricted mice
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE93747 | GEO | 2018/01/18
SECONDARY ACCESSION(S): PRJNA362285
REPOSITORIES: GEO
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Project description:Caloric restriction (CR) enhances the function of adult stem cells and significantly extends the lifespan of many organisms including rodents. CR increases the expression of Period genes in several tissues in mice, and the circadian machinery is strongly influenced by feeding and metabolic pathways. Importantly, Bmal1-deficient mice, or Period/Timeless-deficient Drosophila are refractory to the lifespan extension induced by CR. We therefore studied whether CR could prevent the ageing related circadian reprogramming we had observed in epidermal SCs.
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