Interrogation of functional cell surface markers identifies CD151 dependency in high-grade serous ovarian cancer
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ABSTRACT: The high degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression analysis of cell surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HGSC tumors. Moreover, we show that high CD151 expression is prognostic of poor clinical outcome. This study reveals cell-surface vulnerabilities associated with HGSC, provides a framework for identifying therapeutic targets, and reports a role for CD151 in HGSC.
ORGANISM(S): Homo sapiens
PROVIDER: GSE94304 | GEO | 2017/02/03
SECONDARY ACCESSION(S): PRJNA369618
REPOSITORIES: GEO
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