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BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

ABSTRACT: BRCA1 associated protein 1 (BAP1) is a tumor suppressor with de-ubiquitinating (DUB) enzyme activity and has been implicated in chromatin regulation of gene transcription. The goal of this study is to identify BAP1-dependent transcriptional alterations under both basal (25 mM glucose) and glucose starvation (0 mM glucose) conditions. To this end, we established UMRC6 cell lines (a BAP1 deficient renal cancer cell line) stably expressing Flag-tagged BAP1 wild-type (U6-F), and the empty vector control cells (U6-EV), and performed RNA sequencing (RNA-Seq) analysis in U6-EV and U6-F stable cell lines at 0, 4, and 8 hour upon glucose starvation. The RNA-Seq datasets allow us to compare BAP1-dependent transcriptional alterations under both basal and glucose deprivation conditions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95097 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA376054

REPOSITORIES: GEO

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Genome wide binding sites of BAP1, HCF1 and OGT

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Genome wide binding sites of BAP1, HCF1 and OGT

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