Transcriptomics

Dataset Information

0

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator [RNA-seq]


ABSTRACT: Here we show that ZBTB48 binds directly both to telomeric as well as to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric function, we demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE96777 | GEO | 2017/05/11

SECONDARY ACCESSION(S): PRJNA379623

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-05-11 | GSE96776 | GEO
2017-05-11 | PXD006074 | Pride
2020-11-20 | PXD021085 | Pride
2016-06-21 | GSE83510 | GEO
2018-07-12 | GSE98981 | GEO
2017-05-10 | GSE86964 | GEO
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
2024-08-26 | GSE228607 | GEO
2024-08-26 | GSE228606 | GEO
2024-08-26 | GSE228605 | GEO