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Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression

ABSTRACT: Gene expression changes induced by acute skeletal muscle unloading, which leads to physiological changes including muscle atrophy, fibre-type switching, and loss of ability to transition between lipid and glucose as energy source (metabolic inflexibility), was investigated by hind-limb suspension (HLS) treatment of Male ICR mice (28–32 g body wt; Harlan, Indianapolis, IN). Agilent Whole Mouse Genome Oligo Microarrays were utilised to examine the effects of HLS on mRNA expression profiles of the soleus muscle and the gastrocnemius muscle in the hindlimbs of freely ambulating control and 24h HLS treated mice. Keywords: treatment vs control, tissue type comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE9802 | GEO | 2008/12/01

SECONDARY ACCESSION(S): PRJNA103747

REPOSITORIES: GEO

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Transcription profiling ofmouse skeletal muscle to investigate the effect profiling ofacute muscle unloading on soleus and gastrocnemius muscle gene expression

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