Other

Dataset Information

0

Dynamic Maps of UV Damage Formation and Repair for the Human Genome


ABSTRACT: UV-induced DNA damage is the major carcinogen of skin cancer. We developed HS-Damage-seq to map UV damage with unprecedented sensitivity and resolution in human cells. While the distribution of UV-induced damage are mainly determined by sequence context and essentially uniform throughout the genome, transcription factors can affect damage formation at specific positions. With time-course experiments, we observed changes in damage distribution at particular genomic loci and chromatin states, which reflects the nucleotide excision repair preferences and complements the repair maps by XR-seq. Our results demonstrated that while initial damage is uniformly distributed, they are heterogeneously repaired throughout the genome. The combination of damage and repair maps provides a holistic perspective of UV damage and repair in the human genome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE98025 | GEO | 2017/06/27

SECONDARY ACCESSION(S): PRJNA383707

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2015-04-19 | E-GEOD-67941 | biostudies-arrayexpress
2020-04-06 | GSE145883 | GEO
2024-05-27 | GSE268350 | GEO
2024-05-27 | GSE268349 | GEO
2015-04-19 | GSE67941 | GEO
2024-04-02 | GSE262486 | GEO
2022-02-25 | GSE184926 | GEO
2016-03-15 | E-GEOD-76391 | biostudies-arrayexpress
2018-04-12 | GSE110621 | GEO
2020-04-09 | GSE148303 | GEO