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Effects of dominant-negative Smarca4 mutations on the DNA accessibility landscape [ATAC-seq]

ABSTRACT: We generated a library of Smarca4 variants with mutations in conserved regions of the N-terminal ATPase domain based on mutants observed in primary tumors and cancer cell lines. Heterozygous expression of Smarca4 ATPase mutants led to decreased accessibility at active enhancers in mouse embryonic stem cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE98486 | GEO | 2017/10/22

SECONDARY ACCESSION(S): PRJNA385199

REPOSITORIES: GEO

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