Transcriptomics

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Gene expression profiling in acute murine autoimmune hepatitis


ABSTRACT: The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways dependent on IFN-γ as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice

ORGANISM(S): Mus musculus

PROVIDER: GSE9892 | GEO | 2009/02/28

SECONDARY ACCESSION(S): PRJNA103887

REPOSITORIES: GEO

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