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Targeted next generation sequencing of 589 genes identifies complementary responses in t-helper-like T regulatory cells

ABSTRACT: Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral immunological tolerance, by preventing autoimmunity and chronic inflammation. However, they can also play a parallel role in the promotion of antitumor responses. Tregs can be classified as T helper (Th)-like Tregs that phenotypically resemble Th1/Th2/Th17/TH1-TH17 lineages based upon the expression of specific chemokine receptors and transcription factors. The distribution of these Treg subsets can provide mechanistic insights into disease processes, therefore we sought to characterise their immune transcriptome. Targeted RNA sequencing revealed that circulating Th2-like Tregs displayed higher viability and activation as well as suggesting specific disease pathways associated to sifferent T reg subtypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99733 | GEO | 2017/06/12

SECONDARY ACCESSION(S): PRJNA389449

REPOSITORIES: GEO

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