Therapeutic antibodies to ganglioside GD2 evolved from highly selective germline antibodies I

ABSTRACT: Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. Conclusion: Antibodies to GD2 evolved from highly specific germlines. Highly specific germlines may be critical in evading autoimmunity issues.

ORGANISM(S): Bos taurus Dermestes lardarius Mus musculus Sus scrofa domesticus Human immunodeficiency virus 1 Homo sapiens unidentified Oryctolagus cuniculus Trypanosoma cruzi Ovis aries Frangula alnus Gossypium hirsutum Pachymenia carnosa Quercus alba Rhodotorula Ceratonia siliqua Pandalus borealis Megathura crenulata Senegalia senegal Bothrops moojeni Oncorhynchus nerka Gallus gallus

PROVIDER: GSE99872 | GEO | 2017/08/25

SECONDARY ACCESSION(S): PRJNA391733

REPOSITORIES: GEO