Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS - Methanobacter - Natural Product screen

ABSTRACT: Non-targted LC-MS/MS natural product screening of methane bacterium.

INSTRUMENT(S): Q-Exactive

ORGANISM(S): Methanobacterium (ncbitaxon:2160)

SUBMITTER: Aaron Puri

PROVIDER: MSV000080974 | GNPS | Thu Apr 20 21:44:00 BST 2017

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS - Methylobacter Natural Product Discovery

Project description:Non-targted MS/MS screening and structure elucidation of natural products from Methylobacter tundripaludum.

2017-05-08 | MSV000081064 | GNPS

GNPS - Non-targted MS/MS Natural Product Screening of Pseudomonas strains

Project description:Non-targted MS/MS Natural Product Screening of three bacterial isolates of the genus Pseudomonas, native from agricultural soils in Argentina, that produce surfactant molecules. Pseudomonas chlororaphis SMMP3 Pseudomonas sp. SVMP4 Pseudomonas sp. SBMP6

2020-02-26 | MSV000085024 | GNPS

GNPS - Non-targeted Metabolomics Plant Microbiome Screen

Project description:Non-targeted LC-MS/MS based Metabolomics of Plant Microbiome strain for natural product Screening

2024-06-25 | MSV000095148 | GNPS

The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway

Project description:The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway

2017-06-12 | GSE93558 | GEO

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Project description:Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have larger BGC repertoires than others, we hypothesized that a set of genes co-evolved with BGCs to support biosynthetic proficiency must exist in those strains, and that their identification may provide universal strategies to improve the productivity of other strains. We show here that genes co-evolved with natural product BGCs in Streptomyces can be identified by phylogenomics analysis. Among the 597 genes that co-evolved with polyketide BGCs, 11 genes in the “coenzyme” category have been examined, including a gene cluster encoding for the co-factor pyrroloquinoline quinone (PQQ). When the pqq gene cluster was engineered into 11 Streptomyces strains, it enhanced production of 16,385 metabolites, including 36 known natural products with up to 40-fold improvement and several activated silent gene clusters. This study provides a new engineering strategy for improving polyketide production and discovering new biosynthetic gene clusters.

2024-03-01 | GSE256209 | GEO

Antimalarial mechanism of action of the natural product 9-methoxystrobilurin G

Project description:Antimalarial mechanism of action of the natural product 9-methoxystrobilurin G

2024-09-11 | PXD053143 | Pride

The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa

Project description:Natural products represent a rich source for antibiotics addressing versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we select elegaphenone, a largely uncharacterized natural product antibiotic bearing a native benzophenone core scaffold, for affinity-based protein profiling (AfBPP) in Gram-positive and Gram-negative bacteria. This study utilizes the alkynylated natural product scaffold as a probe to uncover intriguing biological interactions with the transcriptional regulator AlgP. Furthermore, proteome profiling of a Pseudomonas aeruginosa AlgP transposon mutant revealed unique insights into the mode of action. Elegaphenone enhanced the killing of intracellular P. aeruginosa in macrophages exposed to sub-inhibitory concentrations of the fluoroquinolone antibiotic norfloxacin.

2021-09-08 | PXD010476 | Pride

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Project description:Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

| PRJNA1078415 | ENA

Bioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS

Project description:Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive components are required to keep pace with the expanding fungal repertoire. We developed PepSAVI-MS to expedite the search for natural product bioactive peptides and herein demonstrate proof-of-principle applicability of the pipeline for the discovery of bioactive peptides from fungal secretomes via identification of the antifungal killer toxin KP4 from Ustilago maydis P4. This work opens the door to investigating microbial secretomes with a new lens, and could have broad applications across human health, agriculture, and food safety.

2018-02-19 | PXD006931 | Pride

Transcriptome Profile of Natural Product Deoxyshikonin Induced Gene Expression in IPEC-J2

Project description:Transcriptome Profile of Natural Product Deoxyshikonin Induced Gene Expression in IPEC-J2

| PRJNA729652 | ENA