Project description:Toy dataset for a workshop on GNPS at Imperial College London, UK.
Breadth samples for early diagnose of gastric/oesophageal cancer
Project description:Infected neonatal mouse cardiomyocyte COMMENT: Submitter has not provided GEO with full dataset as described in Nat Genet. 2004 Feb;36(2):123-30. Keywords: parallel sample
Project description:This work focuses on understanding the molecular basis of the immune dysfunctions in Idiopathic CD4+ T cells lymphocytopenia (ICL). ICL is a rare haematological disorder of unknown origin, characterized by a profound and persistent CD4+ T-cell defect, which predisposes to life threatening opportunistic infections very similar to those seen in AIDS. To analyse more in depth the functional pathways involved in ICL pathogenesis, we conducted gene expression profiling of CD4+ T-cells isolated from blood samples from ICL, sarcoidosis and healthy individuals. Our analyses have revealed specific CD4+ T-cells gene expression signatures in ICL associated with defective TCR activation threshold, expansion of the Treg-cell compartment and interestingly with accelerated immune aging. 25 Total samples were analyzed. We generated the following pairwise comparisons using GenoSplice technology. We permormed multiple anlayses including : ICL vs Healthy (All or paired samples), ICL vs SARC (All or paired samples) and SARC vs Healthy (All or paired sample). Paired samples means that a same healthy individual was using in comparaison of a ICL or SARC subjects. Genes with a Fold-change ? 1,5 and P-Value ? 0,05 were selected.
Project description:Infected neonatal mouse cardiomyocyte; COMMENT: Submitter has not provided GEO with full dataset as described in Nat Genet. 2004 Feb;36(2):123-30.
Project description:This work focuses on understanding the molecular basis of the immune dysfunctions in Idiopathic CD4+ T cells lymphocytopenia (ICL). ICL is a rare haematological disorder of unknown origin, characterized by a profound and persistent CD4+ T-cell defect, which predisposes to life threatening opportunistic infections very similar to those seen in AIDS. To analyse more in depth the functional pathways involved in ICL pathogenesis, we conducted gene expression profiling of CD4+ T-cells isolated from blood samples from ICL, sarcoidosis and healthy individuals. Our analyses have revealed specific CD4+ T-cells gene expression signatures in ICL associated with defective TCR activation threshold, expansion of the Treg-cell compartment and interestingly with accelerated immune aging.