Metabolomics

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GNPS Lipidomics of zebrafish liver tissues

ABSTRACT: Application of an untargeted liquid chromatography- high resolution mass spectrometry platform for lipidomics profiling of zebrafish liver tissues

INSTRUMENT(S): 6560 Q-TOF LC/MS

ORGANISM(S): Danio Rerio (ncbitaxon:7955)

SUBMITTER: Katyeny Manuela da Silva  

PROVIDER: MSV000088860 | GNPS | Fri Feb 18 02:09:00 GMT 2022

REPOSITORIES: GNPS

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Lipidomics profiling of zebrafish liver through untargeted liquid chromatography-high resolution mass spectrometry.

da Silva Katyeny Manuela KM   Iturrospe Elias E   van den Boom Rik R   van de Lavoir Maria M   Robeyns Rani R   Vergauwen Lucia L   Knapen Dries D   Cuykx Matthias M   Covaci Adrian A   van Nuijs Alexander L N ALN  

Journal of separation science 20220703 15

Lipidomics analysis of zebrafish tissues has shown promising results to understand disease-related outcomes of exposure to toxic substances at a molecular level. However, knowledge about their lipidome is limited, as most untargeted studies only identify the lipids that are statistically significant in their setup. In this work, liquid chromatography-high resolution mass spectrometry was used to study different aspects of the analytical workflow, that is, extraction solvents (methanol/chloroform  ...[more]

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