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GNPS - Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

ABSTRACT: Targeted GC-MS detection of host and dietary metabolites and modifications by gut bacteria.

INSTRUMENT(S): Agilent 7890A GC system, Agilent 5975C MS detector

ORGANISM(S): Eggerthella Lenta (ncbitaxon:84112) Holdemania Filiformis (ncbitaxon:61171) Sutterella Wadsworthensis (ncbitaxon:40545)

SUBMITTER: Sam Light

PROVIDER: MSV000093291 | GNPS | Fri Nov 03 12:37:00 GMT 2023

REPOSITORIES: GNPS

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Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.

Little Alexander S AS Younker Isaac T IT Schechter Matthew S MS Bernardino Paola Nol PN Méheust Raphaël R Stemczynski Joshua J Scorza Kaylie K Mullowney Michael W MW Sharan Deepti D Waligurski Emily E Smith Rita R Ramanswamy Ramanujam R Leiter William W Moran David D McMillin Mary M Odenwald Matthew A MA Iavarone Anthony T AT Sidebottom Ashley M AM Sundararajan Anitha A Pamer Eric G EG Eren A Murat AM Light Samuel H SH

Nature microbiology 20240104 1

Respiratory reductases enable microorganisms to use molecules present in anaerobic ecosystems as energy-generating respiratory electron acceptors. Here we identify three taxonomically distinct families of human gut bacteria (Burkholderiaceae, Eggerthellaceae and Erysipelotrichaceae) that encode large arsenals of tens to hundreds of respiratory-like reductases per genome. Screening species from each family (Sutterella wadsworthensis, Eggerthella lenta and Holdemania filiformis), we discover 22 me ...[more]

PMID: 38177297

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