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Gated phosphorylated proteomics of LAIR1-overexpressed and LAIR1-control in GL261 cells

ABSTRACT: The total protein in GL261 cells was extracted, part of it was taken out for protein concentration determination and SDS-PAGE detection, and the other part was taken for trypsin digestion, peptide desalting, phosphorylation modification peptide enrichment and purification, and finally 4D-Labelfree detection and data analysis of the sample.

ORGANISM(S): Mus Musculus

SUBMITTER: Huanli Xu

PROVIDER: PXD042932 | iProX | Tue Jun 13 00:00:00 BST 2023

REPOSITORIES: iProX

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LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines.

Wei Xiaoqian X Pan Shushan S Wang Zirui Z Chen Jieru J Lu Li L Cao Qizhi Q Song Shuling S Zhang Huachang H Liu Xiaohui X Qu Xianjun X Lin Xiukun X Xu Huanli H

Cell death & disease 20231016 10

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR1), an immune receptor containing immunoreceptor tyrosine-based inhibiory motifs (ITIMs), has emerged as an attractive target for cancer therapy. However, the intrinsic function of LAIR1 in gliomas remains unclear. In this study, the poor prognosis of glioma patients and the malignant proliferation of glioma cells in vitro and in vivo were found to be closely correlated with LAIR1. LAIR1 facilitates focal adhesion kinase (FAK) nuclear loca ...[more]

PMID: 37845206

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