Anti-Influenza Activity of the Ribonuclease Binase in A549 cells

ABSTRACT: Ribonucleases (RNases) of different origin demonstrate antiviral effects that are mediated by the direct RNase action on RNA species and can also involve signal transduction modulation. To reveal cellular targets and explain the mechanisms underlying the antiviral effect employed by the small extra-cellular ribonuclease of Bacillus pumilus (binase) both in vitro and in vivo, a shotgun proteomic analysis of influenza A virus (H1N1pdm09)-infected A549 cells upon binase treatment, was performed.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Raihan Shah Mahmud 

PROVIDER: PXD013540 | JPOST Repository | Wed Apr 17 00:00:00 BST 2019

REPOSITORIES: jPOST