Dataset Information

CoRest’s acetylation acts as a temporal gate for activity-dependent transcription, limiting behavioral flexibility in Drosophila

ABSTRACT: In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed to determine the acetylation site of CoRest, the Rpd3 interacting protein, purified from mushroom body.

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: Yukinori Hirano

PROVIDER: PXD021294 | JPOST Repository | Mon Dec 07 00:00:00 GMT 2020

REPOSITORIES: jPOST

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Dataset's files

Source:

			Action	DRS
	SN170725_Rpd3_TRPA1%20heat%20shock(-).mgf	Mgf
	SN170725_Rpd3_TRPA1%20heat%20shock(-).mzid	Mzid
	SN170725_Rpd3_TRPA1%20heat%20shock(-).raw	Raw
	SN170726_Rpd3_TRPA1%20heat%20shock%201h.mgf	Mgf
	SN170726_Rpd3_TRPA1%20heat%20shock%201h.raw	Raw

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Publications

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.

Takakura Mai M Nakagawa Reiko R Ota Takeshi T Kimura Yoko Y Ng Man Yung MY Alia Abdalla G AG Okuno Hiroyuki H Hirano Yukinori Y

Nature communications 20210127 1

Consolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the com ...[more]

PMID: 33504795

Dataset Information

CoRest’s acetylation acts as a temporal gate for activity-dependent transcription, limiting behavioral flexibility in Drosophila

Dataset's files

Publications

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.

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