Dataset Information
Analysis of Mettl1 interacting proteins in Drosophila
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
SUBMITTER: Kuniaki Saito
PROVIDER: PXD044501 | JPOST Repository | Tue Aug 20 00:00:00 BST 2024
REPOSITORIES: jPOST
Publications
Mettl1-dependent m<sup>7</sup>G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster.
Nature communications 20240924 1
Modification of guanosine to N<sup>7</sup>-methylguanosine (m<sup>7</sup>G) in the variable loop region of tRNA is catalyzed by the METTL1/WDR4 heterodimer and stabilizes target tRNA. Here, we reveal essential functions of Mettl1 in Drosophila fertility. Knockout of Mettl1 (Mettl1-KO) causes no major effect on the development of non-gonadal tissues, but abolishes the production of elongated spermatids and mature sperm, which is fully rescued by expression of a Mettl1-transgene, but not a catalyt ...[more]
