Dataset Information

Identifying potential interacting proteins of Drosophila Evi5

ABSTRACT: In order to understand the function of Evi5 in iron homeostasis and steroid hormone production, we performed a MALDI-TOF mass spectrometry to identify candidate interacting proteins with Drosophila Evi5 both in vivo and ex vivo.

INSTRUMENT(S): LTQ

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Whole Body, S2 Cell

SUBMITTER: Sattar Soltani

LAB HEAD: Sattar Soltani

PROVIDER: PXD041626 | Pride | 2024-05-21

REPOSITORIES: Pride

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Publications

Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.

Soltani Sattar S Webb Samuel M SM Kroll Thomas T King-Jones Kirst K

Nature communications 20240514 1

Vesicular transport is essential for delivering cargo to intracellular destinations. Evi5 is a Rab11-GTPase-activating protein involved in endosome recycling. In humans, Evi5 is a high-risk locus for multiple sclerosis, a debilitating disease that also presents with excess iron in the CNS. In insects, the prothoracic gland (PG) requires entry of extracellular iron to synthesize steroidogenic enzyme cofactors. The mechanism of peripheral iron uptake in insect cells remains controversial. We show ...[more]

PMID: 38744835

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