Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Taisuke Kato
PROVIDER: PXD023477 | JPOST Repository | Tue Nov 16 00:00:00 GMT 2021
REPOSITORIES: jPOST
Action | DRS | |||
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PK20043-Re.sdia | Other | |||
R001_PK20033-1_Htra1_KO1.raw | Raw | |||
R002_PK20033-3_Htra1_KO2.raw | Raw | |||
R004_PK20043-2_Htra1_KO3.raw | Raw | |||
R006_PK20033-5_Htra1_KO_Cande1.raw | Raw |
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The Journal of clinical investigation 20211101 22
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high-temperature requirement A1 (HTRA1) serine protease activity. In CARASIL, arteriopathy causes intimal thickening, smooth muscle cell (SMC) degeneration, elastic lamina splitting, and vasodilation. The molecular mechanisms were proposed to involve the a ...[more]