Proteomics

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Differences in protein domains between c-MYC and L-MYC during cellular reprogramming

ABSTRACT: MYC proteins (c-MYC, n-MYC, and L-MYC) are essential for improving reprogramming efficiency. L-MYC can generate iPSC colonies more efficiently than c-MYC. Still, it remains unknown what is the functional differences between c-MYC and L-MYC during cellular reprogramming. In this study, we performed proteome analysis to tackle this question and found MYC Box 0 (MB0) and 2 (MB2), one of the functional domains conserved in MYC family protein, might cause the phenotypic differences between the MYC proteins.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Mio Iwasaki 

PROVIDER: PXD027086 | JPOST Repository | Fri Jan 07 00:00:00 GMT 2022

REPOSITORIES: jPOST

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Dataset's files

Source:
Action DRS
201225mi-12-cMyc-MB0-WT-Lmyc-MB0-WT-iTRAQ-set1-500ng-225min_Slot1-04_1_5500.tdf Other
201225mi-13-cMyc-MB0-WT-Lmyc-MB0-WT-iTRAQ-set1-500ng-225min_Slot1-04_1_5501.tdf Other
201225mi-15-cMyc-MB0-WT-Lmyc-MB0-WT-iTRAQ-set2-500ng-225min_Slot1-05_1_5503.tdf Other
201225mi-16-cMyc-MB0-WT-Lmyc-MB0-WT-iTRAQ-set2-500ng-225min_Slot1-05_1_5504.tdf Other
201225mi-16-cMyc-MB0-WT-Lmyc-MB0-WT-iTRAQ-set2-500ng-225min_Slot1-05_1_5504.tdf_bin Other
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Publications

MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains.

Akifuji Chiaki C   Iwasaki Mio M   Kawahara Yuka Y   Sakurai Chiho C   Cheng Yu-Shen YS   Imai Takahiko T   Nakagawa Masato M  

Scientific reports 20211220 1

Human induced pluripotent stem cells (hiPSCs) can differentiate into cells of the three germ layers and are promising cell sources for regenerative medicine therapies. However, current protocols generate hiPSCs with low efficiency, and the generated iPSCs have variable differentiation capacity among different clones. Our previous study reported that MYC proteins (c-MYC and MYCL) are essential for reprogramming and germline transmission but that MYCL can generate hiPSC colonies more efficiently t  ...[more]

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