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Proteogenomic and expression profiling of Marek's disease virus during fully productive replication in the host

ABSTRACT: Feather follicle epithelium samples were collected from chickens that were infected with Marek's disease virus (MDV). The proteome and phosphoproteome of MDV were then interrogated by high resolution LC-MS.

ORGANISM(S): Gallid Alphaherpesvirus 2

SUBMITTER: Keith W. Jarosinski

PROVIDER: PXD040077 | JPOST Repository | Mon Jun 05 00:00:00 BST 2023

REPOSITORIES: jPOST

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			Action	DRS
	21-123-Jarosinski-global%20WT%202.mzML	Mzml
	21-123-Jarosinski-global%20WT%203.mzML	Mzml
	21-123-Jarosinski-global-proteome-Mock-1.raw	Raw
	21-123-Jarosinski-global-proteome-Mock-2.raw	Raw
	21-123-Jarosinski-global-proteome-Mock-3.raw	Raw

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Publications

Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host.

Volkening Jeremy D JD Spatz Stephen J SJ Ponnuraj Nagendraprabhu N Akbar Haji H Arrington Justine V JV Vega-Rodriguez Widaliz W Jarosinski Keith W KW

PLoS pathogens 20230608 6

Efficient transmission of herpesviruses is essential for dissemination in host populations; however, little is known about the viral genes that mediate transmission, mostly due to a lack of natural virus-host model systems. Marek's disease is a devastating herpesviral disease of chickens caused by Marek's disease virus (MDV) and an excellent natural model to study skin-tropic herpesviruses and transmission. Like varicella zoster virus that causes chicken pox in humans, the only site where infect ...[more]

PMID: 37289833

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