Dataset Information
HLA-I and HLA-II peptidomes of endometrial cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Takayuki Kanaseki
PROVIDER: PXD050576 | JPOST Repository | Thu Oct 31 00:00:00 GMT 2024
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ST756_UTE07tumor_classII_1.mgf | Mgf | |||
| ST756_UTE07tumor_classII_1.raw | Raw | |||
| ST756_UTE07tumor_classII_2.mgf | Mgf | |||
| ST756_UTE07tumor_classII_2.raw | Raw | |||
| ST756_UTE07tumor_classII_3.mgf | Mgf |
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Publications
Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer.
Cancer immunology research 20250201 2
Tumor-reactive CD4+ T cells often accumulate in the tumor microenvironment (TME) in human cancer, but their functions and roles in antitumor responses remain elusive. Here, we investigated the immunopeptidome of HLA class II-positive (HLA-II+) endometrial cancer with an inflamed TME using a proteogenomic approach. We identified HLA-II neoantigens, one of which induced polyclonal CD4+ tumor-infiltrating lymphocyte responses. We then experimentally demonstrated that neoantigen-specific CD4+ tumor- ...[more]
