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Human Ebola Virus Disease Pathogenesis Multi-Platform Omics Analysis

ABSTRACT: Multi-platform omics analyses of peripheral blood mononuclear cells and plasma derived from human patients infected with Ebola virus.

INSTRUMENT(S): Agilent GC/MSD 5975C

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Richard D. Smith

PROVIDER: MSV000080129 | MassIVE |

REPOSITORIES: MassIVE

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A compendium of multi-omics data illuminating host responses to lethal human virus infections.

Eisfeld Amie J AJ Anderson Lindsey N LN Fan Shufang S Walters Kevin B KB Halfmann Peter J PJ Westhoff Smith Danielle D Thackray Larissa B LB Tan Qing Q Sims Amy C AC Menachery Vineet D VD Schäfer Alexandra A Sheahan Timothy P TP Cockrell Adam S AS Stratton Kelly G KG Webb-Robertson Bobbie-Jo M BM Kyle Jennifer E JE Burnum-Johnson Kristin E KE Kim Young-Mo YM Nicora Carrie D CD Peralta Zuleyma Z N'jai Alhaji U AU Sahr Foday F van Bakel Harm H Diamond Michael S MS Baric Ralph S RS Metz Thomas O TO Smith Richard D RD Kawaoka Yoshihiro Y Waters Katrina M KM

Scientific data 20240402 1

Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were im ...[more]

PMID: 38565538

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