Dataset Information
Mycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Exactive Plus Orbitrap (Thermo Scientific)
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773)
SUBMITTER: Kimberly E. Beatty
PROVIDER: MSV000080238 | MassIVE | Mon Oct 10 21:04:00 BST 2016
SECONDARY ACCESSION(S): PXD005127
REPOSITORIES: MassIVE
Publications
Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis.
ACS infectious diseases 20161013 12
Mycobacterium tuberculosis (Mtb) is the deadliest bacterial pathogen in the world. An estimated one-third of humans harbor Mtb in a dormant state. These asymptomatic, latent infections impede tuberculosis eradication due to the long-term potential for reactivation. Dormant Mtb has reduced enzymatic activity, but hydrolases that remain active facilitate pathogen survival. We targeted Mtb esterases, a diverse set of enzymes in the serine hydrolase family, and studied their activities using both ac ...[more]
