Dataset Information

Hela-S3 ATPome

ABSTRACT: ATP binding proteins (ATPome) dataset and ATPome-wide selectivity profiling of staurosporine and (s)-crizotinib

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Jun Adachi

PROVIDER: MSV000080281 | MassIVE | Sun Oct 23 15:22:00 BST 2016

SECONDARY ACCESSION(S): PXD001200

REPOSITORIES: MassIVE

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Publications

Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe.

Adachi Jun J Kishida Marina M Watanabe Shio S Hashimoto Yuuki Y Fukamizu Kazuna K Tomonaga Takeshi T

Journal of proteome research 20140930 12

ATP-binding proteins, including protein kinases, play essential roles in many biological and pathological processes and thus these proteins are attractive as drug targets. Acyl-ATP probes have been developed as efficient probes for kinase enrichment, and these probes have also been used to enrich other ATP-binding proteins. However, a robust method to identify ATP-binding proteins with systematic elimination of nonspecific binding proteins has yet to be established. Here, we describe an ATP comp ...[more]

PMID: 25230287

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