Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Susumu Y. Imanishi
PROVIDER: MSV000080775 | MassIVE | Wed Mar 29 13:15:00 BST 2017
SECONDARY ACCESSION(S): PXD001374
REPOSITORIES: MassIVE
Kauko Otto O Laajala Teemu Daniel TD Jumppanen Mikael M Hintsanen Petteri P Suni Veronika V Haapaniemi Pekka P Corthals Garry G Aittokallio Tero T Westermarck Jukka J Imanishi Susumu Y SY
Scientific reports 20150817
Hyperactivated RAS drives progression of many human malignancies. However, oncogenic activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) activity. Although PP2A is known to regulate some of the RAS effector pathways, it has not been systematically assessed how these proteins functionally interact. Here we have analyzed phosphoproteomes regulated by either RAS or PP2A, by phosphopeptide enrichment followed by mass-spectrometry-based label-free quantification ...[more]