Proteomics

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Large bidirectional remodeling of the Myc-induced cell surface proteome in B-cells and prostate cells creates new opportunities for immunotherapy


ABSTRACT: To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered to contain either high or low MYC.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: James Wells  

PROVIDER: MSV000085930 | MassIVE | Fri Aug 07 19:40:00 BST 2020

SECONDARY ACCESSION(S): PXD020799

REPOSITORIES: MassIVE

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Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.

Chen Wentao W   Mou Kurt Yun KY   Solomon Paige P   Aggarwal Rahul R   Leung Kevin K KK   Wells James A JA  

Proceedings of the National Academy of Sciences of the United States of America 20210101 4


MYC is a powerful transcription factor overexpressed in many human cancers including B cell and prostate cancers. Antibody therapeutics are exciting opportunities to attack cancers but require knowledge of surface proteins that change due to oncogene expression. To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on 800 surface proteins in three isogenic model cell lines e  ...[more]

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