Proteomics

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Top-Down Characterization of an Intact Monoclonal Antibody using Activated Ion-Electron Transfer Dissociation


ABSTRACT: Here, we examined the utility of AI-ETD for sequencing of the intact NIST monoclonal antibody on a modified Fusion Lumos Orbitrap platform using direct infusion. We also tested other dissociation techniques including HCD, ETD, and EThcD.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Jean Lodge  

PROVIDER: MSV000086331 | MassIVE | Mon Oct 19 12:19:00 BST 2020

REPOSITORIES: MassIVE

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