Dataset Information
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Thermo Orbitrap Elite mass spectrometer
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Rushika M. Perera
PROVIDER: MSV000086769 | MassIVE | Tue Jan 26 17:25:00 GMT 2021
REPOSITORIES: MassIVE
Publications
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
Nature cell biology 20210308 3
Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity of the lysosome membrane facilitate pancreatic cancer growth. Using proteomic-based organelle profiling, we identify the Ferlin family plasma membr ...[more]
