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Gut microbial communities enriched with quaternary amines

ABSTRACT: Human fecal communities were dosed with either choline, carnitine, butyrobetaine, or glycine betaine to measure the microbial response to quaternary amine addition. Samples were digested with trypsin, and analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.

INSTRUMENT(S): Q Exactive Plus, Q Exactive HF

ORGANISM(S): Unclassified Bacteria (ncbitaxon:2323)

SUBMITTER: Kelly Wrighton

PROVIDER: MSV000087004 | MassIVE | Thu Mar 04 22:02:00 GMT 2021

SECONDARY ACCESSION(S): PXD024537

REPOSITORIES: MassIVE

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Publications

Targeted curation of the gut microbial gene content modulating human cardiovascular disease.

Borton Mikayla A MA Shaffer Michael M Hoyt David W DW Jiang Ruisheng R Ellenbogen Jared B JB Purvine Samuel S Nicora Carrie D CD Eder Elizabeth K EK Wong Allison R AR Smulian A George AG Lipton Mary S MS Krzycki Joseph A JA Wrighton Kelly C KC

mBio 20230911 5

<h4>Importance</h4>One of the most-cited examples of the gut microbiome modulating human disease is the microbial metabolism of quaternary amines from protein-rich foods. By-products of this microbial processing promote atherosclerotic heart disease, a leading cause of human mortality globally. Our research addresses current knowledge gaps in our understanding of this microbial metabolism by holistically inventorying the microorganisms and expressed genes catalyzing critical atherosclerosis-prom ...[more]

PMID: 37695138

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