Proteomics

Dataset Information

0

Omics Reveal Far Reaching Effects of Verapamil Treatment in Subjects with Type 1 Diabetes

ABSTRACT: Proteomic data from recent onset T1D patients treated with verapamil where significant extension of the honeymoon phase was observed. Samples were depleted with MARS Hu-14 column, digested with trypsin, labeled with 11-plex TMT, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline. TMT data was extracted using PlexedPiper.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei-Jun Qian  

PROVIDER: MSV000087598 | MassIVE | Wed Jun 09 14:14:00 BST 2021

SECONDARY ACCESSION(S): PXD026601

REPOSITORIES: MassIVE

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications

Currently, no oral medications are available for type 1 diabetes (T1D). While our recent randomized placebo-controlled T1D trial revealed that oral verapamil had short-term beneficial effects, their duration and underlying mechanisms remained elusive. Now, our global T1D serum proteomics analysis identified chromogranin A (CHGA), a T1D-autoantigen, as the top protein altered by verapamil and as a potential therapeutic marker and revealed that verapamil normalizes serum CHGA levels and reverses T  ...[more]

Similar Datasets

Proteomics Defining the dynamic regulation of O-GlcNAc proteome in the mouse cortex -- The O-GlcNAcylation of synaptic and trafficking proteins related to neurodegenerative diseases
| MSV000088053 | MassIVE
Proteomics Regulation of hyperoxia-induced neonatal lung injury via posttranslational cysteine redox modifications
2022-08-18 | MSV000090157 | MassIVE
Proteomics Hepatic SerpinA1 Improves Energy and Glucose Metabolism through Regulation of Preadipocyte Proliferation and UCP1 Expression
2023-11-21 | MSV000093454 | MassIVE
Proteomics Plasma Protein Signatures in Alcoholic Hepatitis
2019-11-01 | MSV000084528 | MassIVE
Proteomics Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
2021-05-29 | MSV000087543 | MassIVE
Proteomics Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
2020-04-16 | MSV000085298 | MassIVE
Proteomics Evaluating the performance of 193 nm ultraviolet photodissociaiton (UVPD) for tandem mass tag (TMT) labeled peptides
2020-08-31 | MSV000086049 | MassIVE
Proteomics Moisture Modulates Soil Reservoirs of Active DNA and RNA viruses
| MSV000086144 | MassIVE
Proteomics Phosphoproteomic Response of Cardiac Endothelial Cells to Ischemic Injury and Ultrasound
2020-12-31 | MSV000086652 | MassIVE
Proteomics Columbia River sediment HUM-V (Hyporheic Uncultured Microbial and Viral) database metaproteome
2021-04-28 | MSV000087330 | MassIVE