Integration of Proteomics, Phosphoproteomics and Kinomics Enables the Discovery of Anticancer Drugs for Pancreatic Cancer
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ABSTRACT: Here we performed phosphoproteomic, kinome examination of surgical specimens and patient-derived cancer cell lines.Kinomics and phosphoproteomics identified changes in the activity of a number of identical protein kinases in PDAC tumors and tissue culture cells. This allowed us to use these kinases as small molecular inhibitor targets for successful in vitro PDAC cell eradication.
INSTRUMENT(S): Synapt G2 HDMS
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Algirdas Kaupinis
PROVIDER: MSV000089736 | MassIVE | Mon Jun 27 04:02:00 BST 2022
REPOSITORIES: MassIVE
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