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Phosphorylation in the Hippocampal Tissue of 3-week NPC1-null Mice

ABSTRACT: TMT10plex-labeled, phospho-enriched, fractionated sample from the hippocampus of the NPC1-null mouse model was collected using nanoflow-LC-MS. Our goal is to identify signaling changes at an early time-point in the NPC1-null mouse model.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Stephanie Cologna

PROVIDER: MSV000090262 | MassIVE |

REPOSITORIES: MassIVE

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Publications

Comparative Hippocampal Proteome and Phosphoproteome in a Niemann-Pick, Type C1 Mouse Model Reveal Insights into Disease Mechanisms.

Nguyen Thu T A TTA Mohanty Varshasnata V Yan Ying Y Francis Kevin R KR Cologna Stephanie M SM

Journal of proteome research 20231124 1

Niemann-Pick disease, type C (NPC) is a neurodegenerative, lysosomal storage disorder in individuals carrying two mutated copies of either the <i>NPC1</i> or <i>NPC2</i> gene. Consequently, impaired cholesterol recycling and an array of downstream events occur. Interestingly, in NPC, the hippocampus displays lysosomal lipid storage but does not succumb to progressive neurodegeneration as significantly as other brain regions. Since defining the neurodegeneration mechanisms in this disease is stil ...[more]

PMID: 37999680

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