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Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human

ABSTRACT: Astrocytes are a heterogenous population of glial cells that respond to pathological insults or injury by undergoing a profound transformation called reactivity. Reactive astrocytes exhibit distinct, context-dependent cellular, molecular, and functional states that can either help or hinder tissue homeostasis. We recently identified a subtype of reactive astrocytes in the mouse brain called interferon-responsive reactive astrocytes (IRRAs), defined by interferon-responsive genes like Igtp, Ifit3, Oasl, Mx1, Cxcl10, and Gbp2 . To further this transcriptomic definition of IRRAs, we wanted to define the proteomic changes that occur in this sub-state.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Thomas A. Neubert Dr. Shane A. Liddelow

PROVIDER: MSV000091426 | MassIVE | Tue Mar 07 11:49:00 GMT 2023

REPOSITORIES: MassIVE

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